Clomiphene Citrate

Clomiphene Citrate, commonly known as Clomid, is one of the first ovulation introducing agents to treat infertility introduced into the US and was first tested a s a birth control agent.

When you go in for treatment if you are having trouble getting pregnant after 4-6 months if you chart your cycles, or 1 year if you don’t, your doctor, if you don’t go to a specialist, will prescribe clomid to you.

The side effects of Clomid are vast, but they are transient and not severe. They include:
-ovarian enlargement, hot flashes, abdominal discomfort, breast discomfort, nausea, vomiting, visual symptoms, headache, abnormal uterine bleeding, dries up your cervical fluid, and multiple births

Clomid works at the level of the hypothalamus and competes with estrogen receptors causing increased production of FSH (follicle stimulating hormone). This will make your follicles produce TONS more eggs, and therefore you WILL ovulate that cycle. Most times with more than one egg.

Clomid is most likely to be effective in 3-6 ovulatory cycles. It is not meant and not good for long term treatment.

You should have MONTHLY physicals/examinations by physicians while you are on clomid. Even though the side effects are rare, they can happen to you.

Infertility is often overwhelming to a non-specialist since itchanges so often. After clomid sessions of 3-6 months, see a specialist!!

47% of infertility is the man, so specialists always order a semen culture to start. It’s the cheapest, and if it’s the problem, it’s easier and no time is wasted on treating the woman. Also, specialists are more effective at acvancing patients to the next treatment step, such as IUI or IVF.

When you go in for treatment for Clomid, there is a challenge test you have to take at every cycle.

It is a sensitive means to measure ovarian reserve. It is for any woman 38 and over and also anyone with unexplained infertility as about as about 30% in this test will show abnormalities.

It includes:

A). Call the office on Day 1 of menses (not spotting). If on a weekend, call Monday.
B). Come to the office and have blood drawn for an E2 (Estradiol) level and FSH (Follicle Simulating Hormone) level on day 2, 3, or 4 of menses.
C). Begin Clomid – 100 mg/day on day 5 of menses. 2 tables, 50 mg each, taken together at the same time each day.
D). Tablets taken on days 5-9. Return to the office on day 10 or 11 (after 5 days of clomid). FSH level repeated on day 10 or 11.
E). Notified of blood work by your physician.
F). Must sign clomid consent form, which lists possible side effects before starting meds.

If you have a poor clomid challenge test, it indicates it is unlikely the couple would be successful using IVF. Donor eggs IVF is the best option for these couples.

If you show promise, but it didn’t help, they up your dosage of clomid. It can go up to 200 mg per tablet. Which is why you need 3-6 months to try it.

Before, the one problem with clomid was it was $50 for just the medication. Not the blood tests or the physician visits. Now that generics has come out, it is anywhere from $10 to $20 dollars. So now, with the visits and meds, it is about $50 a month or a little more to start on clomid.

It does help most women ovulate. A lot get pregnant with twins, but a lot don’t get pregnant at all on clomid.

If you are having infertility or trouble trying to get pregnant, go in for a clomid challenge test. It may help, but don’t think that if it doesn’t you can’t have children.

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3 Responses

  1. wow, what great information! thanks! I’ve heard of this stuff. I’ve been charting a month and I’m charting this month, we may start trying next month… eek! I hope it works, but I’ll be ok if it doesn’t for 6 months… I think. haha. Thanks for the great post! so helpful!

  2. I love learning about medicine. I guess that’s why I work in a pharmacy. Lol. Love love LOVE the blog! Keep it up!

  3. I’d like to emphasize what Kayce says – IF IT DOESN”T WORK IN 6 MONTHS SEE A SPECIALIST!! If am OB or family practice doc has you taking it for longer they don’t know what they’re doing, they are wasting your time and emotions and potentially damaging your body (from what I understand it is clinically only meant for short term use). Also, you should get bloodwork done every cycle at day 3 and 21 to make sure you ARE ovulating (otherwise that whole wasting your time thing comes into play). And another thing – if clomid makes you crazy hormonal that doesn’t mean other fertility drugs will do the same thing.

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